Drug interactions
Atorvastatin + Momelotinib
Severity: Moderate
Atorvastatin and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP and may raise atorvastatin exposure. This could increase the likelihood of statin-related muscle toxicity.
What this interaction means in plain words
Atorvastatin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Momelotinib belongs to Oncology.
Why it happens
BCRP inhibition by momelotinib increases atorvastatin absorption and reduces efflux.
What to do
Monitor for myopathy symptoms and consider reducing the atorvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Momelotinib
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
- Gemfibrozil + Momelotinib Moderate
Frequently asked questions
Can I take Atorvastatin with Momelotinib?
MediHelp rates the interaction as moderate. Atorvastatin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib inhibits BCRP and may raise atorvastatin exposure. This could increase the likelihood of statin-related muscle toxicity.
How serious is the interaction between Atorvastatin and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy symptoms and consider reducing the atorvastatin dose.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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