Drug interactions
Cyclosporin + Momelotinib
Severity: Moderate
Cyclosporin and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits OATP1B1/1B3 and may raise momelotinib concentrations. Higher exposure could increase adverse effects such as thrombocytopenia, infection and hepatic effects.
What this interaction means in plain words
Cyclosporin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Momelotinib belongs to Oncology.
Why it happens
Cyclosporine inhibits OATP1B1/1B3 uptake of momelotinib.
What to do
Monitor blood counts, liver tests and signs of infection and adverse effects of momelotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
- Gemfibrozil + Momelotinib Moderate
Frequently asked questions
Can I take Cyclosporin with Momelotinib?
MediHelp rates the interaction as moderate. Cyclosporin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits OATP1B1/1B3 and may raise momelotinib concentrations. Higher exposure could increase adverse effects such as thrombocytopenia, infection and hepatic effects.
How serious is the interaction between Cyclosporin and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver tests and signs of infection and adverse effects of momelotinib.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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