Drug interactions
Fluvastatin + Momelotinib
Severity: Moderate
Fluvastatin and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP and may raise exposure to BCRP substrates such as fluvastatin. This could increase statin-related adverse effects including myopathy.
What this interaction means in plain words
Fluvastatin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Momelotinib belongs to Oncology.
Why it happens
Momelotinib inhibits intestinal and hepatic BCRP, increasing fluvastatin absorption and exposure.
What to do
Monitor for muscle symptoms and consider reducing the fluvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Gemfibrozil + Momelotinib Moderate
Frequently asked questions
Can I take Fluvastatin with Momelotinib?
MediHelp rates the interaction as moderate. Fluvastatin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib inhibits BCRP and may raise exposure to BCRP substrates such as fluvastatin. This could increase statin-related adverse effects including myopathy.
How serious is the interaction between Fluvastatin and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider reducing the fluvastatin dose.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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