Drug interactions
Clarithromycin + Momelotinib
Severity: Moderate
Clarithromycin and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib is an OATP1B1/3 substrate, and clarithromycin can inhibit these transporters and raise momelotinib exposure. This may increase momelotinib adverse effects such as thrombocytopenia, GI effects and hypotension.
What this interaction means in plain words
Clarithromycin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Momelotinib belongs to Oncology.
Why it happens
Inhibition of OATP1B1/3 uptake of momelotinib by clarithromycin, with possible CYP3A4 contribution.
What to do
Monitor blood counts and blood pressure, and for momelotinib adverse effects. Reduce the dose or use an alternative antibiotic if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
- Gemfibrozil + Momelotinib Moderate
Frequently asked questions
Can I take Clarithromycin with Momelotinib?
MediHelp rates the interaction as moderate. Clarithromycin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib is an OATP1B1/3 substrate, and clarithromycin can inhibit these transporters and raise momelotinib exposure. This may increase momelotinib adverse effects such as thrombocytopenia, GI effects and hypotension.
How serious is the interaction between Clarithromycin and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and blood pressure, and for momelotinib adverse effects. Reduce the dose or use an alternative antibiotic if toxicity develops.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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