Drug interactions
Erythromycin + Momelotinib
Severity: Moderate
Erythromycin and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase momelotinib exposure by inhibiting OATP1B1/1B3-mediated hepatic uptake. Higher momelotinib levels may increase adverse reactions such as thrombocytopenia, gastrointestinal effects and elevated liver enzymes.
What this interaction means in plain words
Erythromycin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Momelotinib belongs to Oncology.
Why it happens
Erythromycin inhibits OATP1B1/1B3 transporters, reducing hepatic uptake and clearance of momelotinib.
What to do
Monitor for momelotinib adverse reactions, including blood counts and liver tests. Consider an alternative antibiotic if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
- Gemfibrozil + Momelotinib Moderate
Frequently asked questions
Can I take Erythromycin with Momelotinib?
MediHelp rates the interaction as moderate. Erythromycin and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase momelotinib exposure by inhibiting OATP1B1/1B3-mediated hepatic uptake. Higher momelotinib levels may increase adverse reactions such as thrombocytopenia, gastrointestinal effects and elevated liver enzymes.
How serious is the interaction between Erythromycin and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for momelotinib adverse reactions, including blood counts and liver tests. Consider an alternative antibiotic if toxicity appears.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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