Drug interactions
Momelotinib + Telmisartan-amlodipine
Severity: Minor
Momelotinib and Telmisartan-amlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib is an OATP1B1/1B3 substrate, and telmisartan has been reported to inhibit these transporters. Higher momelotinib exposure could increase its adverse effects, although the clinical significance is uncertain.
What this interaction means in plain words
Momelotinib and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Momelotinib belongs to Oncology; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1/1B3-mediated hepatic uptake of momelotinib by telmisartan.
What to do
No dose change is generally required. Monitor for momelotinib adverse effects such as cytopenias, neuropathy and hypotension, especially at treatment start.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Telmisartan-amlodipine?
MediHelp rates the interaction as minor. Momelotinib and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Momelotinib is an OATP1B1/1B3 substrate, and telmisartan has been reported to inhibit these transporters. Higher momelotinib exposure could increase its adverse effects, although the clinical significance is uncertain.
How serious is the interaction between Momelotinib and Telmisartan-amlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Monitor for momelotinib adverse effects such as cytopenias, neuropathy and hypotension, especially at treatment start.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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