Drug interactions
Momelotinib + Telmisartan
Severity: Moderate
Momelotinib and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib is an OATP1B1/3 substrate, and telmisartan may inhibit these transporters and raise momelotinib exposure. This could increase momelotinib adverse effects, although the clinical magnitude is uncertain. Momelotinib may also affect telmisartan through BCRP inhibition.
What this interaction means in plain words
Momelotinib and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Momelotinib belongs to Oncology; Telmisartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/3-mediated hepatic uptake of momelotinib by telmisartan.
What to do
Monitor for momelotinib adverse effects such as thrombocytopenia, neuropathy and hypotension, and adjust per labeling. Check blood pressure if telmisartan effects seem altered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Momelotinib and Telmisartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Telmisartan?
MediHelp rates the interaction as moderate. Momelotinib and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib is an OATP1B1/3 substrate, and telmisartan may inhibit these transporters and raise momelotinib exposure. This could increase momelotinib adverse effects, although the clinical magnitude is uncertain. Momelotinib may also affect telmisartan through BCRP inhibition.
How serious is the interaction between Momelotinib and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for momelotinib adverse effects such as thrombocytopenia, neuropathy and hypotension, and adjust per labeling. Check blood pressure if telmisartan effects seem altered.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
