Drug interactions
Mometasone intranasal + Posaconazole
Severity: Moderate
Mometasone intranasal and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise systemic exposure to mometasone absorbed from the nasal route. This can lead to corticosteroid effects such as adrenal suppression or Cushingoid features, particularly with prolonged use.
What this interaction means in plain words
Mometasone intranasal and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole strongly inhibits CYP3A4, reducing the metabolism of mometasone.
What to do
Monitor for systemic corticosteroid effects during long-term coadministration and consider a non-CYP3A4-dependent alternative such as beclomethasone if therapy is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Mometasone intranasal with Posaconazole?
MediHelp rates the interaction as moderate. Mometasone intranasal and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may raise systemic exposure to mometasone absorbed from the nasal route. This can lead to corticosteroid effects such as adrenal suppression or Cushingoid features, particularly with prolonged use.
How serious is the interaction between Mometasone intranasal and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects during long-term coadministration and consider a non-CYP3A4-dependent alternative such as beclomethasone if therapy is prolonged.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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