Drug interactions
Montelukast + Pentobarbital
Severity: Minor
Montelukast and Pentobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic CYP enzymes and may lower montelukast concentrations with repeated dosing. This could reduce control of asthma or allergic symptoms.
What this interaction means in plain words
Montelukast and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP3A4/CYP2C enzymes increases montelukast clearance.
What to do
Monitor asthma control during prolonged pentobarbital use. Adjust controller therapy if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Montelukast with Pentobarbital?
MediHelp rates the interaction as minor. Montelukast and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentobarbital induces hepatic CYP enzymes and may lower montelukast concentrations with repeated dosing. This could reduce control of asthma or allergic symptoms.
How serious is the interaction between Montelukast and Pentobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control during prolonged pentobarbital use. Adjust controller therapy if symptoms worsen.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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