Drug interactions
Montelukast + Quinupristin / dalfopristin
Severity: Minor
Montelukast and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and might raise montelukast concentrations. Montelukast has a wide therapeutic margin, so a clinically relevant effect is unlikely.
What this interaction means in plain words
Montelukast and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, which contributes to montelukast metabolism.
What to do
No dose adjustment is usually needed; watch for increased adverse effects such as headache or neuropsychiatric symptoms during the short antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Montelukast with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Montelukast and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and might raise montelukast concentrations. Montelukast has a wide therapeutic margin, so a clinically relevant effect is unlikely.
How serious is the interaction between Montelukast and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for increased adverse effects such as headache or neuropsychiatric symptoms during the short antibiotic course.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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