Drug interactions
Morphine + Oxycodone
Severity: Moderate
Morphine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are full mu-opioid agonists, so concurrent use produces additive analgesia, sedation and respiratory depression without a clear benefit over using one drug. Taking them together raises the risk of overdose and opioid-related adverse effects.
What this interaction means in plain words
Morphine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive mu-opioid receptor agonism.
What to do
Avoid duplicate opioid therapy unless deliberately planned, such as breakthrough dosing, and calculate the total daily morphine-equivalent dose. Monitor sedation and respiratory rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Morphine with Oxycodone?
MediHelp rates the interaction as moderate. Morphine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are full mu-opioid agonists, so concurrent use produces additive analgesia, sedation and respiratory depression without a clear benefit over using one drug. Taking them together raises the risk of overdose and opioid-related adverse effects.
How serious is the interaction between Morphine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate opioid therapy unless deliberately planned, such as breakthrough dosing, and calculate the total daily morphine-equivalent dose. Monitor sedation and respiratory rate.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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