Drug interactions
Morphine + Ozanimod
Severity: Moderate
Morphine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and opioids with serotonergic properties carry a theoretical risk of serotonin syndrome or hypertensive reactions. Morphine has weak serotonergic activity so the risk is likely low.
What this interaction means in plain words
Morphine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by ozanimod metabolite, with potential additive serotonergic or sympathomimetic effects.
What to do
Monitor blood pressure and watch for signs of serotonin toxicity, such as agitation, tremor and hyperthermia. Prefer a non-serotonergic analgesic if concerns arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Morphine with Ozanimod?
MediHelp rates the interaction as moderate. Morphine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, and opioids with serotonergic properties carry a theoretical risk of serotonin syndrome or hypertensive reactions. Morphine has weak serotonergic activity so the risk is likely low.
How serious is the interaction between Morphine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and watch for signs of serotonin toxicity, such as agitation, tremor and hyperthermia. Prefer a non-serotonergic analgesic if concerns arise.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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