Drug interactions
Morphine + Ranolazine
Severity: Minor
Morphine and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits CYP2D6 weakly, and morphine is not primarily metabolized by this enzyme, so a clinically meaningful rise in morphine exposure is unlikely. Ranolazine may inhibit P-glycoprotein, which could modestly raise morphine levels.
What this interaction means in plain words
Morphine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Morphine belongs to Musculoskeletal; Ranolazine belongs to Cardiovascular.
Why it happens
Weak CYP2D6 and P-glycoprotein inhibition by ranolazine; morphine is cleared mainly by glucuronidation.
What to do
No empirical dose adjustment is needed. Monitor for unusual sedation or respiratory depression when starting ranolazine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Morphine and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Morphine with Ranolazine?
MediHelp rates the interaction as minor. Morphine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine inhibits CYP2D6 weakly, and morphine is not primarily metabolized by this enzyme, so a clinically meaningful rise in morphine exposure is unlikely. Ranolazine may inhibit P-glycoprotein, which could modestly raise morphine levels.
How serious is the interaction between Morphine and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Monitor for unusual sedation or respiratory depression when starting ranolazine.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
