Drug interactions
Morphine + Rizatriptan
Severity: Minor
Morphine and Rizatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to serotonergic effects, so combining them could theoretically cause serotonin syndrome. In practice, reports are rare and the risk is considered low.
What this interaction means in plain words
Morphine and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Morphine belongs to Musculoskeletal; Rizatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity (5-HT1B/1D agonism with weak opioid serotonergic effects); not well established for morphine.
What to do
No routine change is needed. Educate the patient on symptoms such as agitation, tremor, sweating and hyperthermia and review the regimen if they develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Morphine with Rizatriptan?
MediHelp rates the interaction as minor. Morphine and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been linked to serotonergic effects, so combining them could theoretically cause serotonin syndrome. In practice, reports are rare and the risk is considered low.
How serious is the interaction between Morphine and Rizatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Educate the patient on symptoms such as agitation, tremor, sweating and hyperthermia and review the regimen if they develop.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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