Drug interactions
Morphine + Sevoflurane
Severity: Moderate
Morphine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids reduce the concentration of sevoflurane needed for anesthesia, but together they deepen respiratory depression and can cause hypotension and bradycardia. Postoperative sedation and ventilatory depression may be prolonged.
What this interaction means in plain words
Morphine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression between opioid agonism and volatile anesthetic action.
What to do
Adjust the sevoflurane concentration to effect and monitor ventilation and hemodynamics throughout. Observe closely in recovery for delayed respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Morphine with Sevoflurane?
MediHelp rates the interaction as moderate. Morphine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids reduce the concentration of sevoflurane needed for anesthesia, but together they deepen respiratory depression and can cause hypotension and bradycardia. Postoperative sedation and ventilatory depression may be prolonged.
How serious is the interaction between Morphine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust the sevoflurane concentration to effect and monitor ventilation and hemodynamics throughout. Observe closely in recovery for delayed respiratory depression.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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