Drug interactions
Morphine + Stiripentol
Severity: Moderate
Morphine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and can add to the CNS depression produced by morphine. It may also inhibit P-glycoprotein and raise morphine exposure, although the clinical significance is not well defined.
What this interaction means in plain words
Morphine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible P-glycoprotein inhibition by stiripentol.
What to do
Monitor for excessive sedation and respiratory depression, and reduce the morphine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Morphine with Stiripentol?
MediHelp rates the interaction as moderate. Morphine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and can add to the CNS depression produced by morphine. It may also inhibit P-glycoprotein and raise morphine exposure, although the clinical significance is not well defined.
How serious is the interaction between Morphine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and reduce the morphine dose if adverse effects occur.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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