Drug interactions
Morphine + Trazodone
Severity: Moderate
Morphine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone adds sedation to morphine and may increase the risk of respiratory depression and orthostatic hypotension. Both drugs have serotonergic activity, so serotonin syndrome is a possible but uncommon risk.
What this interaction means in plain words
Morphine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible additive serotonergic effects.
What to do
Start with low doses and titrate carefully, monitoring sedation and blood pressure. Watch for agitation, tremor, hyperthermia or clonus suggesting serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Morphine with Trazodone?
MediHelp rates the interaction as moderate. Morphine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone adds sedation to morphine and may increase the risk of respiratory depression and orthostatic hypotension. Both drugs have serotonergic activity, so serotonin syndrome is a possible but uncommon risk.
How serious is the interaction between Morphine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate carefully, monitoring sedation and blood pressure. Watch for agitation, tremor, hyperthermia or clonus suggesting serotonin toxicity.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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