Drug interactions
Morphine + Trimipramine
Severity: Moderate
Morphine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is highly sedating and increases the CNS and respiratory depressant effects of morphine. Anticholinergic effects such as constipation and urinary retention may also be worsened, and serotonergic toxicity is a possible risk.
What this interaction means in plain words
Morphine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects, with possible additive serotonergic activity.
What to do
Use lower doses and titrate slowly, monitoring sedation, respiration and bowel and bladder function. Be alert for signs of serotonin syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Morphine with Trimipramine?
MediHelp rates the interaction as moderate. Morphine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is highly sedating and increases the CNS and respiratory depressant effects of morphine. Anticholinergic effects such as constipation and urinary retention may also be worsened, and serotonergic toxicity is a possible risk.
How serious is the interaction between Morphine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower doses and titrate slowly, monitoring sedation, respiration and bowel and bladder function. Be alert for signs of serotonin syndrome.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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