Drug interactions
Morphine + Vortioxetine
Severity: Moderate
Morphine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine has serotonergic activity through reuptake inhibition and receptor effects, and with opioids may contribute to serotonin syndrome. Morphine has weak serotonergic action so the risk is low but not negligible.
What this interaction means in plain words
Morphine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, with vortioxetine increasing synaptic serotonin.
What to do
Monitor for features of serotonin toxicity after starting or raising doses. Reduce or stop one agent if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Morphine with Vortioxetine?
MediHelp rates the interaction as moderate. Morphine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine has serotonergic activity through reuptake inhibition and receptor effects, and with opioids may contribute to serotonin syndrome. Morphine has weak serotonergic action so the risk is low but not negligible.
How serious is the interaction between Morphine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin toxicity after starting or raising doses. Reduce or stop one agent if symptoms appear.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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