Drug interactions
Moxifloxacin + Quetiapine
Severity: Major
Moxifloxacin and Quetiapine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Their combination increases the risk of torsades de pointes, particularly with electrolyte disturbance, bradycardia or structural heart disease.
What this interaction means in plain words
Moxifloxacin and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Moxifloxacin belongs to Anti Bacterial; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation via cardiac potassium channel blockade.
What to do
Avoid if possible and choose an alternative antibiotic. If used together, obtain a baseline ECG, monitor QTc and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Moxifloxacin with Quetiapine?
MediHelp rates the interaction as major. Moxifloxacin and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval. Their combination increases the risk of torsades de pointes, particularly with electrolyte disturbance, bradycardia or structural heart disease.
How serious is the interaction between Moxifloxacin and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative antibiotic. If used together, obtain a baseline ECG, monitor QTc and keep potassium and magnesium normal.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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