Drug interactions
Moxifloxacin + Quinidine
Severity: Contraindicated
Moxifloxacin and Quinidine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong ventricular repolarization, and combining them increases the risk of torsades de pointes and other serious arrhythmias. Moxifloxacin labeling cautions against use with class IA antiarrhythmics.
What this interaction means in plain words
Moxifloxacin and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Moxifloxacin belongs to Anti Bacterial; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through blockade of cardiac potassium channels.
What to do
Avoid the combination and select a non-QT-prolonging antibiotic. If exposure has occurred, obtain an ECG and correct potassium and magnesium.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Moxifloxacin and Quinidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Quinidine?
MediHelp rates the interaction as contraindicated. Moxifloxacin and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong ventricular repolarization, and combining them increases the risk of torsades de pointes and other serious arrhythmias. Moxifloxacin labeling cautions against use with class IA antiarrhythmics.
How serious is the interaction between Moxifloxacin and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-QT-prolonging antibiotic. If exposure has occurred, obtain an ECG and correct potassium and magnesium.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
