Drug interactions
Moxifloxacin + Saxagliptin-metformin
Severity: Moderate
Moxifloxacin and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients with diabetes, particularly older adults and those with renal impairment. Moxifloxacin carries a lower dysglycemia risk than some other agents in the class, but the effect remains clinically relevant.
What this interaction means in plain words
Moxifloxacin and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic effect, as fluoroquinolones may alter pancreatic beta-cell insulin release.
What to do
Monitor blood glucose during therapy and advise the patient to report symptoms of low or high glucose. Consider an alternative antibiotic if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Moxifloxacin and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients with diabetes, particularly older adults and those with renal impairment. Moxifloxacin carries a lower dysglycemia risk than some other agents in the class, but the effect remains clinically relevant.
How serious is the interaction between Moxifloxacin and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during therapy and advise the patient to report symptoms of low or high glucose. Consider an alternative antibiotic if glucose becomes unstable.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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