Drug interactions
Moxifloxacin + Sertraline
Severity: Moderate
Moxifloxacin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline has a low potential for QT prolongation, but combined with moxifloxacin there may be a small additive effect. The risk is mainly relevant in patients with other arrhythmia risk factors.
What this interaction means in plain words
Moxifloxacin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Sertraline belongs to Central Nervous System.
Why it happens
Mild additive effects on ventricular repolarization.
What to do
Check the baseline QTc and correct electrolyte disturbances. Obtain a follow-up ECG in patients with cardiac disease or additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Sertraline?
MediHelp rates the interaction as moderate. Moxifloxacin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline has a low potential for QT prolongation, but combined with moxifloxacin there may be a small additive effect. The risk is mainly relevant in patients with other arrhythmia risk factors.
How serious is the interaction between Moxifloxacin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline QTc and correct electrolyte disturbances. Obtain a follow-up ECG in patients with cardiac disease or additional QT-prolonging drugs.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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