Drug interactions
Moxifloxacin + Sulindac
Severity: Moderate
Moxifloxacin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones may provoke CNS stimulation and seizures, and NSAIDs may increase this risk in susceptible individuals. The absolute risk is low but the consequence is serious.
What this interaction means in plain words
Moxifloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism at GABA-A receptors, possibly potentiated by NSAIDs; not fully characterized.
What to do
Avoid in patients with a seizure disorder or CNS lesions and choose another antibiotic if needed. Otherwise monitor for neurological symptoms and discontinue moxifloxacin if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Sulindac?
MediHelp rates the interaction as moderate. Moxifloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones may provoke CNS stimulation and seizures, and NSAIDs may increase this risk in susceptible individuals. The absolute risk is low but the consequence is serious.
How serious is the interaction between Moxifloxacin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with a seizure disorder or CNS lesions and choose another antibiotic if needed. Otherwise monitor for neurological symptoms and discontinue moxifloxacin if they occur.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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