Drug interactions
Moxifloxacin + Tolazamide
Severity: Moderate
Moxifloxacin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause severe hypoglycemia in patients taking sulfonylureas, and glucose can also rise. Risk is greater in older patients and those with renal impairment.
What this interaction means in plain words
Moxifloxacin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Tolazamide belongs to Endocrine.
Why it happens
Additive stimulation of pancreatic beta-cell insulin secretion.
What to do
Monitor blood glucose closely during moxifloxacin therapy and reduce the sulfonylurea dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Moxifloxacin with Tolazamide?
MediHelp rates the interaction as moderate. Moxifloxacin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause severe hypoglycemia in patients taking sulfonylureas, and glucose can also rise. Risk is greater in older patients and those with renal impairment.
How serious is the interaction between Moxifloxacin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during moxifloxacin therapy and reduce the sulfonylurea dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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