Drug interactions
Moxifloxacin + Umeclidinium-vilanterol
Severity: Major
Moxifloxacin and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin is among the fluoroquinolones with the greatest QT-prolonging effect. Combined with vilanterol, which can lower potassium and stimulate the heart, the risk of torsades de pointes may rise.
What this interaction means in plain words
Moxifloxacin and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Moxifloxacin belongs to Anti Bacterial; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-agonist-related hypokalemia and sympathetic stimulation.
What to do
Consider an alternative antibiotic with less QT effect. If combined, correct electrolytes and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Moxifloxacin and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Moxifloxacin is among the fluoroquinolones with the greatest QT-prolonging effect. Combined with vilanterol, which can lower potassium and stimulate the heart, the risk of torsades de pointes may rise.
How serious is the interaction between Moxifloxacin and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic with less QT effect. If combined, correct electrolytes and monitor the ECG.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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