Drug interactions
Moxonidine + Prochlorperazine
Severity: Moderate
Moxonidine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, and moxonidine also lowers blood pressure while prochlorperazine can cause orthostatic hypotension. Together they may increase sedation and dizziness or falls, particularly in older adults.
What this interaction means in plain words
Moxonidine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive hypotensive effects (central imidazoline agonism plus alpha-adrenergic blockade).
What to do
Monitor blood pressure, including standing readings, and sedation when starting or increasing either drug. Counsel on rising slowly and avoiding driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Moxonidine with Prochlorperazine?
MediHelp rates the interaction as moderate. Moxonidine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, and moxonidine also lowers blood pressure while prochlorperazine can cause orthostatic hypotension. Together they may increase sedation and dizziness or falls, particularly in older adults.
How serious is the interaction between Moxonidine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, and sedation when starting or increasing either drug. Counsel on rising slowly and avoiding driving until tolerance is established.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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