Drug interactions
Moxonidine + Propofol
Severity: Moderate
Moxonidine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive with sedative effects, and it may add to the sedative and hypotensive effects of propofol. The combination may produce deeper sedation and a larger fall in blood pressure during anesthesia or sedation.
What this interaction means in plain words
Moxonidine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotension from central alpha-2/imidazoline receptor agonism combined with propofol.
What to do
Titrate propofol cautiously with a possibly reduced dose and monitor blood pressure, heart rate and sedation depth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Moxonidine with Propofol?
MediHelp rates the interaction as moderate. Moxonidine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive with sedative effects, and it may add to the sedative and hypotensive effects of propofol. The combination may produce deeper sedation and a larger fall in blood pressure during anesthesia or sedation.
How serious is the interaction between Moxonidine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously with a possibly reduced dose and monitor blood pressure, heart rate and sedation depth.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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