Drug interactions
Mycophenolate mofetil + Pivmecillinam
Severity: Minor
Mycophenolate mofetil and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pivmecillinam is a penicillin-class prodrug and no well-documented interaction with mycophenolate exists. Penicillins may modestly alter mycophenolic acid exposure through gut flora effects on enterohepatic recycling, but this is not established as clinically significant.
What this interaction means in plain words
Mycophenolate mofetil and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mycophenolate mofetil belongs to Miscellaneous; Pivmecillinam belongs to Anti Bacterial.
Why it happens
No established mechanism; antibiotic effects on gut flora may reduce enterohepatic recycling of mycophenolic acid.
What to do
No routine change is needed; watch for reduced immunosuppressive effect if prolonged antibiotic courses are given and consider monitoring clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Mycophenolate mofetil with Pivmecillinam?
MediHelp rates the interaction as minor. Mycophenolate mofetil and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pivmecillinam is a penicillin-class prodrug and no well-documented interaction with mycophenolate exists. Penicillins may modestly alter mycophenolic acid exposure through gut flora effects on enterohepatic recycling, but this is not established as clinically significant.
How serious is the interaction between Mycophenolate mofetil and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for reduced immunosuppressive effect if prolonged antibiotic courses are given and consider monitoring clinical response.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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