Drug interactions
Mycophenolate mofetil + Probenecid
Severity: Moderate
Mycophenolate mofetil and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits renal tubular secretion of mycophenolic acid glucuronide and can raise concentrations of both the glucuronide and mycophenolic acid. This may increase the risk of mycophenolate adverse effects such as leukopenia and gastrointestinal toxicity.
What this interaction means in plain words
Mycophenolate mofetil and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Probenecid belongs to Genitourinary.
Why it happens
Inhibition of renal tubular anion transport of mycophenolic acid glucuronide, reducing its clearance.
What to do
Monitor blood counts and consider reducing the mycophenolate dose if toxicity occurs. Consider an alternative to probenecid where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mycophenolate mofetil and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Mycophenolate mofetil with Probenecid?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal tubular secretion of mycophenolic acid glucuronide and can raise concentrations of both the glucuronide and mycophenolic acid. This may increase the risk of mycophenolate adverse effects such as leukopenia and gastrointestinal toxicity.
How serious is the interaction between Mycophenolate mofetil and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and consider reducing the mycophenolate dose if toxicity occurs. Consider an alternative to probenecid where possible.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
