Drug interactions
Mycophenolate mofetil + Vonoprazan
Severity: Moderate
Mycophenolate mofetil and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan strongly suppresses gastric acid, which may reduce absorption of mycophenolate mofetil as seen with proton pump inhibitors. Lower mycophenolic acid exposure may compromise immunosuppression.
What this interaction means in plain words
Mycophenolate mofetil and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Sustained acid suppression reduces dissolution and absorption of mycophenolate mofetil.
What to do
Monitor for rejection or disease activity, and consider mycophenolic acid level monitoring. Enteric-coated mycophenolate sodium may be less affected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Mycophenolate mofetil with Vonoprazan?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan strongly suppresses gastric acid, which may reduce absorption of mycophenolate mofetil as seen with proton pump inhibitors. Lower mycophenolic acid exposure may compromise immunosuppression.
How serious is the interaction between Mycophenolate mofetil and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rejection or disease activity, and consider mycophenolic acid level monitoring. Enteric-coated mycophenolate sodium may be less affected.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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