Drug interactions
Nabilone + Orphenadrin
Severity: Moderate
Nabilone and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone causes drowsiness, dizziness and altered mood or cognition, and orphenadrine adds sedation and anticholinergic effects. Together they may cause pronounced central nervous system impairment and tachycardia.
What this interaction means in plain words
Nabilone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central nervous system depressant and anticholinergic effects.
What to do
Monitor for oversedation, confusion and tachycardia, and start with low doses. Advise against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Orphenadrin?
MediHelp rates the interaction as moderate. Nabilone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone causes drowsiness, dizziness and altered mood or cognition, and orphenadrine adds sedation and anticholinergic effects. Together they may cause pronounced central nervous system impairment and tachycardia.
How serious is the interaction between Nabilone and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and tachycardia, and start with low doses. Advise against driving or operating machinery.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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