Drug interactions
Nabilone + Oxymorphone
Severity: Major
Nabilone and Oxymorphone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymorphone is a potent opioid, and adding nabilone can intensify sedation, dizziness and cognitive impairment. Respiratory depression may be more likely with combined CNS depressants.
What this interaction means in plain words
Nabilone and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabilone belongs to Gastrointestinal Tract; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate, especially during initiation and titration. Advise patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabilone
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Nabilone with Oxymorphone?
MediHelp rates the interaction as major. Nabilone and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxymorphone is a potent opioid, and adding nabilone can intensify sedation, dizziness and cognitive impairment. Respiratory depression may be more likely with combined CNS depressants.
How serious is the interaction between Nabilone and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate, especially during initiation and titration. Advise patients to avoid alcohol and other sedatives.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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