Drug interactions
Nabilone + Secobarbital
Severity: Moderate
Nabilone and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone is a cannabinoid with sedative and psychoactive effects, and secobarbital is a barbiturate hypnotic. Taken together they produce additive central nervous system depression, with greater drowsiness, impaired psychomotor performance and confusion.
What this interaction means in plain words
Nabilone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Secobarbital belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression from cannabinoid receptor agonism and barbiturate enhancement of GABA-A activity.
What to do
Start with the lowest effective doses and warn the patient against driving or operating machinery. Monitor sedation and mental status, and reduce the dose of either drug if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Nabilone with Secobarbital?
MediHelp rates the interaction as moderate. Nabilone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone is a cannabinoid with sedative and psychoactive effects, and secobarbital is a barbiturate hypnotic. Taken together they produce additive central nervous system depression, with greater drowsiness, impaired psychomotor performance and confusion.
How serious is the interaction between Nabilone and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and warn the patient against driving or operating machinery. Monitor sedation and mental status, and reduce the dose of either drug if oversedation occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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