Drug interactions
Nabilone + Sufentanil
Severity: Major
Nabilone and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a very potent opioid that depresses consciousness and breathing, and nabilone adds CNS depression. Combined use can cause deeper sedation and respiratory depression than either alone.
What this interaction means in plain words
Nabilone and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabilone belongs to Gastrointestinal Tract; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid agonism and cannabinoid receptor activity.
What to do
Give sufentanil only with appropriate monitoring of sedation and ventilation, and reduce opioid dose as needed. Be ready to support ventilation and use naloxone if opioid-related respiratory depression occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabilone
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Nabilone with Sufentanil?
MediHelp rates the interaction as major. Nabilone and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a very potent opioid that depresses consciousness and breathing, and nabilone adds CNS depression. Combined use can cause deeper sedation and respiratory depression than either alone.
How serious is the interaction between Nabilone and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give sufentanil only with appropriate monitoring of sedation and ventilation, and reduce opioid dose as needed. Be ready to support ventilation and use naloxone if opioid-related respiratory depression occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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