Drug interactions
Nabilone + Thioridazine
Severity: Moderate
Nabilone and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is a sedating phenothiazine antipsychotic, and nabilone adds further sedation and psychomotor impairment. Nabilone can also cause tachycardia and orthostatic hypotension, which may add to the cardiovascular effects of thioridazine.
What this interaction means in plain words
Nabilone and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and overlapping autonomic and cardiovascular effects.
What to do
Monitor sedation, blood pressure and heart rate, and reduce doses if excessive drowsiness or hypotension occurs. Counsel the patient about driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nabilone and Thioridazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabilone
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Nabilone with Thioridazine?
MediHelp rates the interaction as moderate. Nabilone and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine is a sedating phenothiazine antipsychotic, and nabilone adds further sedation and psychomotor impairment. Nabilone can also cause tachycardia and orthostatic hypotension, which may add to the cardiovascular effects of thioridazine.
How serious is the interaction between Nabilone and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and reduce doses if excessive drowsiness or hypotension occurs. Counsel the patient about driving and fall risk.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
