Drug interactions
Nabilone + Ziprasidone
Severity: Moderate
Nabilone and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is an antipsychotic that causes sedation and QT prolongation, and nabilone adds to the sedation and can cause tachycardia and orthostatic hypotension. The combination may cause more drowsiness, dizziness and cardiovascular effects.
What this interaction means in plain words
Nabilone and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and overlapping cardiovascular effects; nabilone has no established effect on QT.
What to do
Monitor sedation, blood pressure and heart rate, and reduce doses if symptoms occur. Counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Nabilone with Ziprasidone?
MediHelp rates the interaction as moderate. Nabilone and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone is an antipsychotic that causes sedation and QT prolongation, and nabilone adds to the sedation and can cause tachycardia and orthostatic hypotension. The combination may cause more drowsiness, dizziness and cardiovascular effects.
How serious is the interaction between Nabilone and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and reduce doses if symptoms occur. Counsel on driving and fall risk.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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