Drug interactions
Nabumetone + Pemetrexed
Severity: Major
Nabumetone and Pemetrexed: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can raise pemetrexed exposure by reducing its renal clearance, increasing the risk of myelosuppression, renal toxicity and gastrointestinal toxicity. The risk is greater in patients with mild to moderate renal impairment. Nabumetone has a long active metabolite half-life, so its effect persists for days.
What this interaction means in plain words
Nabumetone and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabumetone belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
Why it happens
NSAID-related reduction in renal blood flow and tubular handling decreases renal elimination of pemetrexed.
What to do
Where possible, withhold nabumetone for several days before, on the day of, and for a couple of days after pemetrexed, following product labeling. If it must continue, monitor blood counts and renal function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Pemetrexed
Frequently asked questions
Can I take Nabumetone with Pemetrexed?
MediHelp rates the interaction as major. Nabumetone and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can raise pemetrexed exposure by reducing its renal clearance, increasing the risk of myelosuppression, renal toxicity and gastrointestinal toxicity. The risk is greater in patients with mild to moderate renal impairment. Nabumetone has a long active metabolite half-life, so its effect persists for days.
How serious is the interaction between Nabumetone and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, withhold nabumetone for several days before, on the day of, and for a couple of days after pemetrexed, following product labeling. If it must continue, monitor blood counts and renal function closely.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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