Drug interactions
Nabumetone + Pivmecillinam
Severity: Minor
Nabumetone and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are acidic and renally cleared, so NSAIDs may reduce tubular secretion of penicillin-type drugs and slightly raise their levels. The effect is generally small and pivmecillinam is used for short courses.
What this interaction means in plain words
Nabumetone and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nabumetone belongs to Musculoskeletal; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Competition for renal tubular secretion of organic anions and possible protein binding competition.
What to do
No dose adjustment is usually needed with a short pivmecillinam course. Monitor for beta-lactam adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Nabumetone with Pivmecillinam?
MediHelp rates the interaction as minor. Nabumetone and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are acidic and renally cleared, so NSAIDs may reduce tubular secretion of penicillin-type drugs and slightly raise their levels. The effect is generally small and pivmecillinam is used for short courses.
How serious is the interaction between Nabumetone and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed with a short pivmecillinam course. Monitor for beta-lactam adverse effects in patients with renal impairment.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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