Drug interactions
Nabumetone + Prednisone
Severity: Moderate
Nabumetone and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using an NSAID together with a systemic corticosteroid increases the risk of peptic ulceration and gastrointestinal bleeding. Nabumetone has somewhat lower GI toxicity than some NSAIDs, but the additive risk still applies.
What this interaction means in plain words
Nabumetone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Prednisone belongs to Endocrine.
Why it happens
Additive pharmacodynamic mucosal injury from prostaglandin inhibition and impaired mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider proton pump inhibitor prophylaxis in higher-risk patients. Monitor for GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Prednisone?
MediHelp rates the interaction as moderate. Nabumetone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using an NSAID together with a systemic corticosteroid increases the risk of peptic ulceration and gastrointestinal bleeding. Nabumetone has somewhat lower GI toxicity than some NSAIDs, but the additive risk still applies.
How serious is the interaction between Nabumetone and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider proton pump inhibitor prophylaxis in higher-risk patients. Monitor for GI bleeding symptoms.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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