Drug interactions
Nabumetone + Probenecid
Severity: Moderate
Nabumetone and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits renal tubular secretion of NSAID metabolites, which can raise NSAID exposure and increase adverse effects such as gastrointestinal and renal toxicity.
What this interaction means in plain words
Nabumetone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits organic anion transporters, reducing renal clearance of the acidic NSAID metabolite.
What to do
Monitor for NSAID adverse effects and consider a lower nabumetone dose. Watch for GI symptoms and renal function changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Nabumetone with Probenecid?
MediHelp rates the interaction as moderate. Nabumetone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal tubular secretion of NSAID metabolites, which can raise NSAID exposure and increase adverse effects such as gastrointestinal and renal toxicity.
How serious is the interaction between Nabumetone and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects and consider a lower nabumetone dose. Watch for GI symptoms and renal function changes.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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