Drug interactions
Nabumetone + Sulindac
Severity: Major
Nabumetone and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together adds no proven benefit and increases the risk of gastrointestinal ulceration and bleeding, renal impairment and cardiovascular events. Both inhibit platelet function and renal prostaglandins.
What this interaction means in plain words
Nabumetone and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabumetone belongs to Musculoskeletal; Sulindac belongs to Musculoskeletal.
Why it happens
Duplicate cyclooxygenase inhibition produces additive gastrointestinal, renal and antiplatelet toxicity.
What to do
Avoid using two systemic NSAIDs together; choose one agent at the lowest effective dose. If an additional analgesic is needed, use paracetamol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Sulindac?
MediHelp rates the interaction as major. Nabumetone and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together adds no proven benefit and increases the risk of gastrointestinal ulceration and bleeding, renal impairment and cardiovascular events. Both inhibit platelet function and renal prostaglandins.
How serious is the interaction between Nabumetone and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two systemic NSAIDs together; choose one agent at the lowest effective dose. If an additional analgesic is needed, use paracetamol.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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