Drug interactions
Nabumetone + Tolazamide
Severity: Minor
Nabumetone and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as tolazamide, occasionally leading to hypoglycemia. The evidence is limited and the effect varies between patients.
What this interaction means in plain words
Nabumetone and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nabumetone belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement from protein binding and prostaglandin-related effects on insulin secretion; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping the NSAID and teach patients to recognise hypoglycemia symptoms. Reduce the tolazamide dose if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Nabumetone with Tolazamide?
MediHelp rates the interaction as minor. Nabumetone and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as tolazamide, occasionally leading to hypoglycemia. The evidence is limited and the effect varies between patients.
How serious is the interaction between Nabumetone and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and teach patients to recognise hypoglycemia symptoms. Reduce the tolazamide dose if glucose falls.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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