Drug interactions
Nabumetone + Tolbutamide
Severity: Minor
Nabumetone and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may modestly enhance the glucose-lowering effect of sulfonylureas such as tolbutamide. Hypoglycemia is possible, particularly in older patients or those with renal impairment. The clinical significance with nabumetone is uncertain and probably small.
What this interaction means in plain words
Nabumetone and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nabumetone belongs to Musculoskeletal; Tolbutamide belongs to Endocrine.
Why it happens
Possible displacement from plasma protein binding or altered renal prostaglandin effects; the mechanism is not firmly established.
What to do
Counsel the patient on hypoglycemia symptoms and check blood glucose when nabumetone is started or stopped. Reduce the tolbutamide dose if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nabumetone and Tolbutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Nabumetone with Tolbutamide?
MediHelp rates the interaction as minor. Nabumetone and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may modestly enhance the glucose-lowering effect of sulfonylureas such as tolbutamide. Hypoglycemia is possible, particularly in older patients or those with renal impairment. The clinical significance with nabumetone is uncertain and probably small.
How serious is the interaction between Nabumetone and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on hypoglycemia symptoms and check blood glucose when nabumetone is started or stopped. Reduce the tolbutamide dose if glucose falls.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
