Drug interactions
Nabumetone + Vancomycin
Severity: Moderate
Nabumetone and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce vancomycin clearance, an effect described mainly in neonates, and both can affect the kidney. In adults the combination may contribute to renal injury, particularly with dehydration or high vancomycin exposure.
What this interaction means in plain words
Nabumetone and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced decrease in renal perfusion and glomerular filtration reduces vancomycin elimination and adds to nephrotoxic potential.
What to do
Monitor serum creatinine and vancomycin levels and adjust the dose as needed. Avoid the NSAID in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Nabumetone with Vancomycin?
MediHelp rates the interaction as moderate. Nabumetone and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce vancomycin clearance, an effect described mainly in neonates, and both can affect the kidney. In adults the combination may contribute to renal injury, particularly with dehydration or high vancomycin exposure.
How serious is the interaction between Nabumetone and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin levels and adjust the dose as needed. Avoid the NSAID in patients with renal impairment.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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