Drug interactions
Nadolol + Succinylcholine
Severity: Minor
Nadolol and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol, a nonselective beta-blocker, can modestly reduce potassium uptake into cells, but the effect on succinylcholine-induced hyperkalemia is minimal. The interaction is mostly theoretical. Nadolol is renally cleared, so accumulation in kidney disease may increase this effect.
What this interaction means in plain words
Nadolol and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nadolol belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Nonselective beta-blockade slightly impairs cellular potassium uptake, which could marginally add to the potassium rise from succinylcholine.
What to do
No routine change is needed. Check potassium in patients with renal impairment before using succinylcholine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Succinylcholine?
MediHelp rates the interaction as minor. Nadolol and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol, a nonselective beta-blocker, can modestly reduce potassium uptake into cells, but the effect on succinylcholine-induced hyperkalemia is minimal. The interaction is mostly theoretical. Nadolol is renally cleared, so accumulation in kidney disease may increase this effect.
How serious is the interaction between Nadolol and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Check potassium in patients with renal impairment before using succinylcholine.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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