Drug interactions
Nafcillin + Vilazodone
Severity: Moderate
Nafcillin and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may reduce vilazodone concentrations, potentially reducing antidepressant effect during the antibiotic course.
What this interaction means in plain words
Nafcillin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induction of CYP3A4 metabolism of vilazodone.
What to do
Monitor for worsening depressive symptoms during and after nafcillin therapy. Consider a vilazodone dose increase within the labeled maximum if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Nafcillin with Vilazodone?
MediHelp rates the interaction as moderate. Nafcillin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin induces CYP3A4 and may reduce vilazodone concentrations, potentially reducing antidepressant effect during the antibiotic course.
How serious is the interaction between Nafcillin and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening depressive symptoms during and after nafcillin therapy. Consider a vilazodone dose increase within the labeled maximum if prolonged therapy is needed.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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