Drug interactions
Nalbuphine + Papaverine
Severity: Minor
Nalbuphine and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine is a smooth muscle relaxant with little clinical sedative effect, so a meaningful additive sedation with nalbuphine is not well established. Any interaction is likely small.
What this interaction means in plain words
Nalbuphine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nalbuphine belongs to Musculoskeletal; Papaverine belongs to Cardiovascular.
Why it happens
Mechanism not well established; possible mild additive central depression or vasodilation-related hypotension.
What to do
No specific action is needed beyond routine monitoring of sedation and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Nalbuphine with Papaverine?
MediHelp rates the interaction as minor. Nalbuphine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine is a smooth muscle relaxant with little clinical sedative effect, so a meaningful additive sedation with nalbuphine is not well established. Any interaction is likely small.
How serious is the interaction between Nalbuphine and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of sedation and blood pressure.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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