Drug interactions
Nalbuphine + Temazepam
Severity: Major
Nalbuphine and Temazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid agonist-antagonist with a benzodiazepine hypnotic produces additive central nervous system depression. This can cause profound sedation, respiratory depression, coma and death, particularly in older or debilitated patients and those with lung disease.
What this interaction means in plain words
Nalbuphine and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nalbuphine belongs to Musculoskeletal; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression through opioid receptor activity and enhanced GABA-A receptor signalling.
What to do
Reserve concurrent use for patients without alternatives, using the lowest effective doses and shortest duration. Monitor respiratory rate and level of sedation, and counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Nalbuphine with Temazepam?
MediHelp rates the interaction as major. Nalbuphine and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid agonist-antagonist with a benzodiazepine hypnotic produces additive central nervous system depression. This can cause profound sedation, respiratory depression, coma and death, particularly in older or debilitated patients and those with lung disease.
How serious is the interaction between Nalbuphine and Temazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest effective doses and shortest duration. Monitor respiratory rate and level of sedation, and counsel patients to avoid alcohol and driving.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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