Drug interactions
Naldemedine + Paliperidone
Severity: Minor
Naldemedine and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a P-glycoprotein substrate, and paliperidone is a weak P-gp substrate and possible mild inhibitor. A clinically meaningful increase in naldemedine exposure is not expected.
What this interaction means in plain words
Naldemedine and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Paliperidone belongs to Central Nervous System.
Why it happens
Possible weak competition at P-glycoprotein efflux transport.
What to do
No dose adjustment needed; watch for naldemedine gastrointestinal effects such as abdominal pain and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Paliperidone?
MediHelp rates the interaction as minor. Naldemedine and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a P-glycoprotein substrate, and paliperidone is a weak P-gp substrate and possible mild inhibitor. A clinically meaningful increase in naldemedine exposure is not expected.
How serious is the interaction between Naldemedine and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; watch for naldemedine gastrointestinal effects such as abdominal pain and diarrhea.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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